The MTHFR gene mutation affects how our bodies process B vitamins for absorption and utilization; this biological process is called methylation. Methylation is simply the transformation of key nutrients into the "activated forms" that our cells can actually use to repair and restore the body towards optimal health. Patients with this gene mutation have significantly reduced MTHFR enzyme activity and therefore require greater supplemental intake of methyl folate, methyl B12, and other cofactor nutrients. Up to 70% of the population is affected by this deficiency. There are now in home DNA tests available that can be found online to assist in determining if one has this genetic mutation. One can supplement with Methylated B Vitamins to assist the body where it is unable to assimilate due to this genetic anomaly.